Ribosome biogenesis and control of cell proliferation: p53 is not alone.

Abstract

Cell growth is a prerequisite for cell proliferation, and ribosome biogenesis is a limiting factor for cell growth. In mammalian cells, the tumor suppressor p53 has been shown to induce cell-cycle arrest in response to impaired ribosome biogenesis. Recently, p53-independent mechanisms of cell-cycle arrest in response to alterations of ribosome biogenesis have been described. These findings provide a rational basis for the use of drugs that specifically impact ribosome biogenesis for the treatment of cancers lacking active p53 and extend the scenario of mechanisms involved in the relationship between cell growth and cell proliferation.

DOI: 10.1158/0008-5472.CAN-11-3992

2 Figures and Tables

050201220132014201520162017
Citations per Year

203 Citations

Semantic Scholar estimates that this publication has 203 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Donati2012RibosomeBA, title={Ribosome biogenesis and control of cell proliferation: p53 is not alone.}, author={Giulio Donati and Lorenzo Montanaro and Massimo Derenzini}, journal={Cancer research}, year={2012}, volume={72 7}, pages={1602-7} }