Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.

@article{Zhu1998RibosomebindingDO,
  title={Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.},
  author={Shunyi Zhu and Ronald C Wek},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 3},
  pages={1808-14}
}
A family of protein kinases regulate translation initiation in response to cellular stresses by phosphorylation of eukaryotic initiation factor-2 (eIF-2). One family member from yeast, GCN2, contains a region homologous to histidyl-tRNA synthetases juxtaposed to the kinase catalytic domain. It is thought that uncharged tRNA accumulating during amino acid starvation binds to the synthetase-related sequences and stimulates phosphorylation of the alpha subunit of eIF-2. In this report, we define… CONTINUE READING
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