Ribosome Induces a Closed to Open Conformational Change in Release Factor 1.


Bacterial translation termination is triggered when a stop codon arrives at the ribosomal A site. Stop codons are recognized by class I release factors (RF1 and RF2 in Escherichia coli), which bind to the ribosome and catalyze the release of the newly synthesized protein. Crystal structures showed that RF1 and RF2 are in an open conformation when bound to… (More)
DOI: 10.1016/j.jmb.2016.01.021