Ribosome Collision Is Critical for Quality Control during No-Go Decay.

@article{Simms2017RibosomeCI,
  title={Ribosome Collision Is Critical for Quality Control during No-Go Decay.},
  author={Carrie L. Simms and Liewei L Yan and Hani S Zaher},
  journal={Molecular cell},
  year={2017},
  volume={68 2},
  pages={
          361-373.e5
        }
}
No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with translational arrests. The process is characterized by an endonucleolytic cleavage near the stall sequence, but the mechanistic details are unclear. Our analysis of cleavage sites indicates that cleavage requires multiple ribosomes on the mRNA. We also show that reporters harboring stall sequences near the initiation codon, which cannot accommodate multiple ribosomes, are not subject to NGD. Consistent with… CONTINUE READING
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