Ribosomal tethering and clustering as mechanisms for translation initiation.

  title={Ribosomal tethering and clustering as mechanisms for translation initiation.},
  author={Stephen A. Chappell and Gerald M. Edelman and Vincent P Mauro},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 48},
Eukaryotic mRNAs often recruit ribosomal subunits some distance upstream of the initiation codon; however, the mechanisms by which they reach the initiation codon remain to be fully elucidated. Although scanning is a widely accepted model, evidence for alternative mechanisms has accumulated. We previously suggested that this process may involve tethering of ribosomal complexes to the mRNA, in which the intervening mRNA is bypassed, or clustering, in which the initiation codon is reached by… CONTINUE READING
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