Ribosomal synthesis of backbone macrocyclic peptides.

  title={Ribosomal synthesis of backbone macrocyclic peptides.},
  author={Takayuki Katoh and Yuki Goto and Md. Shamim Reza and Hiroaki Suga},
  journal={Chemical communications},
  volume={47 36},
A wealth of knowledge has been accumulated on ribosomal synthesis of macrocyclic peptides in the past decade. In nature, backbone cyclization of the translated linear peptides is generally catalyzed by specific enzymes, giving them peptidase resistance, thermodynamic stability and various other physiological activities. Due to these biochemical traits, backbone cyclic peptides have become an attractive resource for the discovery of drug leads. Recently, various new methodologies have also been… CONTINUE READING