Ribosomal release without peptidyl tRNA hydrolysis at translation termination in a eukaryotic system.

Abstract

A 22-codon upstream open reading frame (uORF2) in the human cytomegalovirus UL4 transcript leader inhibits downstream translation in cis. Previous studies revealed that the peptide product of uORF2 mediates this inhibitory effect by interfering with translation termination at its own stop codon. The block at termination results both in accumulation of the… (More)

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