Ribosomal proteins are targets for the NEDD8 pathway.


Identification of the molecular targets for post-translational modifications is an important step for explaining the regulated pathways. The ubiquitin-like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization.

DOI: 10.1038/embor.2008.10

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@article{Xirodimas2008RibosomalPA, title={Ribosomal proteins are targets for the NEDD8 pathway.}, author={Dimitris P. Xirodimas and Anders Sundqvist and Akihiro Nakamura and Linnan Shen and Catherine H. Botting and Ronald T. Hay}, journal={EMBO reports}, year={2008}, volume={9 3}, pages={280-6} }