Ribosomal protein S15 represses its own translation via adaptation of an rRNA-like fold within its mRNA.

@article{Serganov2003RibosomalPS,
  title={Ribosomal protein S15 represses its own translation via adaptation of an rRNA-like fold within its mRNA.},
  author={Alexander Serganov and Ann Polonskaia and Bernard Ehresmann and Chantal Ehresmann and Dinshaw J. Patel},
  journal={The EMBO journal},
  year={2003},
  volume={22 8},
  pages={1898-908}
}
The 16S rRNA-binding ribosomal protein S15 is a key component in the assembly of the small ribosomal subunit in bacteria. We have shown that S15 from the extreme thermophile Thermus thermophilus represses the translation of its own mRNA in vitro, by interacting with the leader segment of its mRNA. The S15 mRNA-binding site was characterized by footprinting experiments, deletion analysis and site-directed mutagenesis. S15 binding triggers a conformational rearrangement of its mRNA into a fold… CONTINUE READING
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