Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.

Abstract

Programmed -1 ribosomal frameshifting is utilized by a number of RNA viruses as a means of ensuring the correct ratio of viral structural to enzymatic proteins available for viral particle assembly. Altering frameshifting efficiencies upsets this ratio, interfering with virus propagation. We have previously demonstrated that compounds that alter the… (More)

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@article{Peltz1999RibosomalPL, title={Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus.}, author={S W Peltz and Amy B Hammell and Y. Cui and Jason Yasenchak and L Puljanowski and Jonathan D. Dinman}, journal={Molecular and cellular biology}, year={1999}, volume={19 1}, pages={384-91} }