Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute.

@article{Oliver2004RibosomalPL,
  title={Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute.},
  author={Edward R Oliver and Thomas Saunders and Susan A. Tarl{\'e} and Tom Glaser},
  journal={Development},
  year={2004},
  volume={131 16},
  pages={3907-20}
}
Ribosomal protein mutations, termed Minutes, have been instrumental in studying the coordination of cell and tissue growth in Drosophila. Although abundant in flies, equivalent defects in mammals are relatively unknown. Belly spot and tail (Bst) is a semidominant mouse mutation that disrupts pigmentation, somitogenesis and retinal cell fate determination. Here, we identify Bst as a deletion within the Rpl24 riboprotein gene. Bst significantly impairs Rpl24 splicing and ribosome biogenesis. Bst… CONTINUE READING