Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing-activated transfer of a mobile genetic element.

@article{Ramsay2015RibosomalFA,
  title={Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing-activated transfer of a mobile genetic element.},
  author={Joshua P. Ramsay and Laura G L Tester and Anthony S Major and John Sullivan and Christina D. Edgar and Torsten Kleffmann and Jackson R Patterson-House and Drew A. Hall and Warren P. Tate and Michael F. Hynes and Clive W Ronson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 13},
  pages={4104-9}
}
Symbiosis islands are integrative and conjugative mobile genetic elements that convert nonsymbiotic rhizobia into nitrogen-fixing symbionts of leguminous plants. Excision of the Mesorhizobium loti symbiosis island ICEMlSym(R7A) is indirectly activated by quorum sensing through TraR-dependent activation of the excisionase gene rdfS. Here we show that a +1 programmed ribosomal frameshift (PRF) fuses the coding sequences of two TraR-activated genes, msi172 and msi171, producing an activator of… CONTINUE READING
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