Ribosomal crystallography: from poorly diffracting microcrystals to high-resolution structures.

@article{Gluehmann2001RibosomalCF,
  title={Ribosomal crystallography: from poorly diffracting microcrystals to high-resolution structures.},
  author={Marco Gluehmann and Raz Zarivach and Anat Bashan and Jean Harms and Frank Schluenzen and Holger Bartels and Ifaat Agmon and Gabriel Rosenblum and Marta Pioletti and Tamar Auerbach and H Avila and Harly A. S. Hansen and Francesco Franceschi and Ada Etil Yonath},
  journal={Methods},
  year={2001},
  volume={25 3},
  pages={292-302}
}
The cellular organelles translating the genetic code into proteins, the ribosomes, are large, asymmetric, flexible, and unstable ribonucleoprotein assemblies, hence they are difficult to crystallize. Despite two decades of intensive effort and thorough searches for suitable sources, so far only three crystal types have yielded high-resolution structures… CONTINUE READING