Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells.

@article{Mariappan2011RibosomalBI,
  title={Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells.},
  author={Meenalakshmi M. Mariappan and Kristin D'Silva and Myung Ja Lee and Kavithalakshmi Sataranatarajan and Jeffrey L. Barnes and Goutam Ghosh Choudhury and Balakuntalam S Kasinath},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={300 1},
  pages={F219-30}
}
Diabetes promotes protein synthesis to induce kidney hypertrophy and increase renal matrix proteins. Increased capacity for mRNA translation by way of ribosomal biogenesis facilitates sustained stimulation of protein synthesis. We tested the hypothesis that high glucose induces ribosomal biogenesis as indicated by an increase in rRNA synthesis in the setting of augmented protein synthesis. High glucose (30 mM) increased global protein synthesis, expression of matrix proteins, laminin γ1 and… CONTINUE READING