Ribosomal antibodies detected by immunofluorescence in systemic lupus erythematosus and other collagenoses.

@article{Homberg1974RibosomalAD,
  title={Ribosomal antibodies detected by immunofluorescence in systemic lupus erythematosus and other collagenoses.},
  author={J. C. Homberg and Mario Rizzetto and Deborah Doniach},
  journal={Clinical and experimental immunology},
  year={1974},
  volume={17 4},
  pages={
          617-28
        }
}
A new ribosomal antibody is described in patients with systemic lupus erythematosus which reacts with all tissues from varied species, giving a distinctive immunofluorescence pattern. This can best be distinguished from other known autoantibodies on stomach where it reacts with chief cells and pancreas where exocrine cells are brightly stained. The ribosomal nature of the antigen was demonstrated by absorption of immunofluorescence and complement fixation studies using purified subcellular… CONTINUE READING

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