Ribosomal acidic phosphoproteins P1 and P2 are not required for cell viability but regulate the pattern of protein expression in Saccharomyces cerevisiae.

@article{Remacha1995RibosomalAP,
  title={Ribosomal acidic phosphoproteins P1 and P2 are not required for cell viability but regulate the pattern of protein expression in Saccharomyces cerevisiae.},
  author={Miguel Remacha and Antonio Jim{\'e}nez-D{\'i}az and Bego{\~n}ia Bermejo and Miguel A. Rodr{\'i}guez-Gabriel and Esther Guarinos and Juan P. G. Ballesta},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 9},
  pages={4754-62}
}
Saccharomyces cerevisiae strains with either three inactivated genes (triple disruptants) or four inactivated genes (quadruple disruptants) encoding the four acidic ribosomal phosphoproteins, YP1 alpha, YP1 beta, YP2 alpha, and YP2 beta, present in this species have been obtained. Ribosomes from the triple disruptants and, obviously, those from the quadruple strain do not have bound P proteins. All disrupted strains are viable; however, they show a cold-sensitive phenotype, growing very poorly… CONTINUE READING

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