Ribosomal RNA introns in archaea and evidence for RNA conformational changes associated with splicing.

@article{Kjems1991RibosomalRI,
  title={Ribosomal RNA introns in archaea and evidence for RNA conformational changes associated with splicing.},
  author={J\orgen Kjems and Roger A. Garrett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 2},
  pages={439-43}
}
The single 23S rRNA gene of the archaeon Staphylothermus marinus exhibits two introns which, at the RNA level, are located in highly conserved regions of domains IV and V. The RNA introns, which are 56 and 54 nucleotides long, respectively, can form single hairpin structures. In vivo, RNA splicing occurs efficiently, whereas in vitro pre-rRNA transcripts containing each intron were cleaved efficiently when incubated with archaeal cell extracts but were poorly ligated. The introns are cleaved by… CONTINUE READING
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