Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.

@article{Honda2005RibosomalRI,
  title={Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.},
  author={Kazuhiro Honda and Mark A Smith and Xiongwei Zhu and Diane Baus and William C. Merrick and Alan Michael Tartakoff and Thomas H. Hattier and Peggy L. R. Harris and Sandra Siedlak and Hisashi Fujioka and Quan Jun Liu and Paula I Moreira and Frank P Miller and Akihiko Nunomura and Shun Shimohama and George Perry},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 22},
  pages={
          20978-86
        }
}
Oxidative modification of cytoplasmic RNA in vulnerable neurons is an important, well documented feature of the pathophysiology of Alzheimer disease. Here we report that RNA-bound iron plays a pivotal role for RNA oxidation in vulnerable neurons in Alzheimer disease brain. The cytoplasm of hippocampal neurons showed significantly higher redox activity and iron(II) staining than age-matched controls. Notably, both were susceptible to RNase, suggesting a physical association of iron(II) with RNA… CONTINUE READING

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14187–14192 rRNA Oxidation by Iron 20986 by gest on A uust 16

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