Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling.

@article{Ciou2015Ribose5phosphateIA,
  title={Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling.},
  author={Shih-Ci Ciou and Y T Chou and Yu-ling Liu and Yu-Chin Nieh and Jeng-Wei Lu and S. -C. Huang and Li-Hao Cheng and Jeng-Fan Lo and Ming-Jen Chen and Ming-Chi Yang and Chiou-Hwa Yuh and H Wang},
  journal={International journal of cancer},
  year={2015},
  volume={137 1},
  pages={104-15}
}
The deregulated nonoxidative pentose phosphate pathway (PPP) is known to promote oncogenesis, but the molecular mechanism remains unknown. Here, we report that human ribose-5-phosphate isomerase A (RPIA) plays a role in human hepatocellular carcinoma (HCC). A significant increase in RPIA expression was detected both in tumor biopsies of HCC patients and in… CONTINUE READING