Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

@article{Zst2011Ribose2P,
  title={Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5},
  author={Roland Z{\"u}st and Luisa Cervantes-Barragan and Matthias Habjan and Reinhard Maier and Benjamin W. Neuman and John Ziebuhr and Kristy J. Szretter and Susan C Baker and Winfried Barchet and Michael S Diamond and Stuart G. Siddell and Burkhard Ludewig and Volker Thiel},
  journal={Nature Immunology},
  year={2011},
  volume={12},
  pages={137-143}
}
The 5′ cap structures of higher eukaryote mRNAs have ribose 2′-O-methylation. Likewise, many viruses that replicate in the cytoplasm of eukaryotes have evolved 2′-O-methyltransferases to autonomously modify their mRNAs. However, a defined biological role for 2′-O-methylation of mRNA remains elusive. Here we show that 2′-O-methylation of viral mRNA was critically involved in subverting the induction of type I interferon. We demonstrate that human and mouse coronavirus mutants lacking 2′-O… CONTINUE READING

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