Ribonucleotide reduction - horizontal transfer of a required function spans all three domains

@inproceedings{Lundin2010RibonucleotideR,
  title={Ribonucleotide reduction - horizontal transfer of a required function spans all three domains},
  author={Daniel Lundin and Simonetta Gribaldo and Eduard Torrents and Britt-Marie Sj{\"o}berg and Anthony M. Poole},
  booktitle={BMC Evolutionary Biology},
  year={2010}
}
Ribonucleotide reduction is the only de novo pathway for synthesis of deoxyribonucleotides, the building blocks of DNA. The reaction is catalysed by ribonucleotide reductases (RNRs), an ancient enzyme family comprised of three classes. Each class has distinct operational constraints, and are broadly distributed across organisms from all three domains, though few class I RNRs have been identified in archaeal genomes, and classes II and III likewise appear rare across eukaryotes. In this study… CONTINUE READING

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