Ribonuclease inhibitor regulates neovascularization by human angiogenin.

@article{Dickson2009RibonucleaseIR,
  title={Ribonuclease inhibitor regulates neovascularization by human angiogenin.},
  author={Kimberly Anne Dickson and Dong-Ku Kang and Young Sam Kwon and Jae Chan Kim and Peter A. Leland and Byung-moon Kim and S Y Chang and Ronald T. Raines},
  journal={Biochemistry},
  year={2009},
  volume={48 18},
  pages={
          3804-6
        }
}
Human angiogenin (ANG) is a homologue of bovine pancreatic ribonuclease (RNase A) that induces neovascularization. ANG is the only human angiogenic factor that possesses ribonucleolytic activity. To stimulate blood vessel growth, ANG must be transported to the nucleus and must retain its catalytic activity. Like other mammalian homologues of RNase A, ANG forms a femtomolar complex with the cytosolic ribonuclease inhibitor protein (RI). To determine whether RI affects ANG-induced angiogenesis… CONTINUE READING

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