Ribonuclease A variants with potent cytotoxic activity.


Select members of the bovine pancreatic ribonuclease A (RNase A) superfamily are potent cytotoxins. These cytotoxic ribonucleases enter the cytosol, where they degrade cellular RNA and cause cell death. Ribonuclease inhibitor (RI), a cytosolic protein, binds to members of the RNase A superfamily with inhibition constants that span 10 orders of magnitude… (More)


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@article{Leland1998RibonucleaseAV, title={Ribonuclease A variants with potent cytotoxic activity.}, author={Pamela Leland and Lyndsie Schultz and B M Kim and R. T. Raines}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1998}, volume={95 18}, pages={10407-12} }