Ribonomic and short hairpin RNA gene silencing methods to explore functional gene programs associated with tumor growth arrest.

@article{Baroni2007RibonomicAS,
  title={Ribonomic and short hairpin RNA gene silencing methods to explore functional gene programs associated with tumor growth arrest.},
  author={Timothy E Baroni and Michele T Lastro and Aparna C. Ranganathan and Scott A. Tenenbaum and Douglas S. Conklin and Julio A. Aguirre-Ghiso},
  journal={Methods in molecular biology},
  year={2007},
  volume={383},
  pages={227-44}
}
In this chapter, we present an approach using genomic and ribonomic profiling to investigate functional gene programs in a tumor growth model. To reach this goal, ribonomic profiling was combined with RNA interference in a tumor dormancy model. Strategies merging functional genomic technologies are outlined for the identification of novel posttranscriptionally regulated targets of p38 to show that they are functionally linked to the induction or interruption of cellular growth in cancer. In the… CONTINUE READING

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