Riboflavin-methotrexate interactions. Photochemical reaction and competition for transport in the L1210 mouse leukemia cell.

@article{Lichtenstein1970RiboflavinmethotrexateIP,
  title={Riboflavin-methotrexate interactions. Photochemical reaction and competition for transport in the L1210 mouse leukemia cell.},
  author={Norman S. Lichtenstein and I. David Goldman},
  journal={Biochemical pharmacology},
  year={1970},
  volume={19 4},
  pages={
          1229-39
        }
}
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16 Citations
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16 Citations

Riboflavin and cancer: a review.

  • R. Rivlin
  • Biology, Medicine
    Cancer research
  • 1973
Much remains to be learned about the uptake, turnover, binding, and removal of riboflavin and its derivatives from neoplastic tissue about the use of folate antagonists in cancer chemotherapy.

Transport and binding of methotrexate in vivo.

This mathematical model is used to interpret data on the uptake of methotrexate in bone marrow, spleen, and small intestine of the bile-cannulated rat following intravenous doses of 0.05,0.25, 2.5, and 25 mg./kg.

Mechanism of Transport of Riboflavin in Rabbit Intestinal Brush Border Membrane Vesicles

RF uptake by rabbit intestinal BBMV occurs via a carrier-mediated system that is Na+ independent in nature and transports the substrate by an electroneutral process, and the role of this system in the overall absorption process of RF is discussed.

Transport of Antineoplastic Agents

Most of the antineoplastic agents whose mode of action is understood appear to act somewhere within the cell, but asparaginase, without entering the cells, causes a critical deficiency of asparagine by cleaving it extracellularly to aspartic acid.

Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells. I. Application to genetic toxicological testing.

Multidrug Transporter ABCG2/Breast Cancer Resistance Protein Secretes Riboflavin (Vitamin B2) into Milk

It is demonstrated that BCRP is responsible for pumping riboflavin (vitamin B2) into milk, thus supplying the young with this important nutrient and establishes the principle that an ABC transporter can transport a vitamin into milk and raises the possibility that other vitamins and nutrients are likewise secreted into milk by ABC transporters.

The inactivation of doxorubicin by long ultraviolet light

The results suggest that the photoinactivation of DOX may involve an oxidation step and it is suggested that patient intake of riboflavin and exposure to the sun and fluorescent light could affect the outcome of anthracycline treatment.

Pharmacokinetic Models for Antineoplastic Agents

The selectivity of most antineoplastic agents depends, in part at least, upon particular differences in cell growth kinetics and pharmacologic effects of drug exposure.

Vitamin B₂: a promising adjuvant in cisplatin based chemoradiotherapy by cellular redox management.

  • I. HassanS. ChibberI. Naseem
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013

Multidrug Transporter ABCG2/Breast Cancer Resistance Protein Secretes Riboflavin (Vitamin B 2 ) into Milk (cid:1)

The principle that an ABC transporter can transport a vitamin into milk is established and the possibility that other vitamins and nutrients are likewise secreted into milk by ABC transporters is raised.

References

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Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.

Transport energetics of the folic acid analogue, methotrexate, in L1210 leukemia cells. Enhanced accumulation by metabolic inhibitors.

  • I. Goldman
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1969
Energy-dependent transport of methotrexate is enhanced in the presence of azide in the L1210 leukemia cell, and it is suggested that azide reduces the maximum transport velocity and the Michaelis constant for the unidirectional efflux process.

On the nature of permeability of sarcoma-180 cells to amethopterin in vitro.

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Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

On the role of drug penetration in amethopterin resistance of Sarcoma-180 cells in vitro.

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COMPLEXING OF RIBOFLAVIN AND ITS 2‐SUBSTITUTED ANALOGS WITH ADENOSINE AND OTHER 6‐SUBSTITUTED PURINE DERIVATIVES*

The results suggest that such groups, including the 6‐amino group of adenine orAdenine moiety of FAD, do not directly interact with flavins by hydrophobic or hydrogen bonding.

Discrimination of Single Transport Systems The Na+-sensitive transport of neutral amino acids in the Ehrlich cell

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THE MECHANISM OF THE FLAVIN SENSITIZED PHOTODESTRUCTION OF INDOLEACETIC ACID*

The results are consistent with a mechanism involving a metastable state of riboflavin as the photochemically reactive species, and the maximum quantum yield of the photoinactivation of IAA is 0.71, indicating a highly efficient process, approaching 100% when energy loss due to rib oflavin fluorescence is taken into account.

Charge-transfer interactions of nucleic acid derivatives.

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Molecular complexes of flavins: a comparison of flavin-indole and flavin-phenol interactions.