Riboflavin analogs and inhibitors of riboflavin biosynthesis

@article{Mack2006RiboflavinAA,
  title={Riboflavin analogs and inhibitors of riboflavin biosynthesis},
  author={M. Mack and S. Grill},
  journal={Applied Microbiology and Biotechnology},
  year={2006},
  volume={71},
  pages={265-275}
}
  • M. Mack, S. Grill
  • Published 2006
  • Chemistry, Medicine
  • Applied Microbiology and Biotechnology
Flavins are active components of many enzymes. In most cases, riboflavin (vitamin B2) as a coenzyme represents the catalytic part of the holoenzyme. Riboflavin is an amphiphatic molecule and allows a large variety of different interactions with the enzyme itself and also with the substrate. A great number of active riboflavin analogs can readily be synthesized by chemical methods and, thus, a large number of possible inhibitors for many different enzyme targets is conceivable. As mammalian and… Expand
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  • S. Chen, C. Shen, +4 authors S. Liaw
  • Biology, Medicine
  • Acta crystallographica. Section D, Biological crystallography
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It was hypothesized that a flavokinase/FAD synthetase (RibC) highly specific for riboflavin may be present in S. davawensis, which would not allow the formation of toxic RoFMN/RoFAD. Expand
The bifunctional flavokinase/FAD synthetase from Streptomyces davawensis produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin
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