Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma

  title={Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma},
  author={Sally Hayes and Craig Boote and Christina S. Kamma-Lorger and Madhavan S Rajan and J. N. Harris and Erin P. Dooley and Nicholas R Hawksworth and Jennifer Hiller and Nick J. Terill and Farhad Hafezi and Arun Brahma and Andrew J Quantock and Keith M. Meek},
  booktitle={PloS one},
PURPOSE To determine the effect of Ultraviolet-A collagen cross-linking with hypo-osmolar and iso-osmolar riboflavin solutions on stromal collagen ultrastructure in normal and keratoconus ex vivo human corneas. METHODS Using small-angle X-ray scattering, measurements of collagen D-periodicity, fibril diameter and interfibrillar spacing were made at 1 mm intervals across six normal post-mortem corneas (two above physiological hydration (swollen) and four below (unswollen)) and two post… CONTINUE READING
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Corneal Collagen Cross-Linking With Riboflavin and UVA Improves Transparency in Hen Corneas

  • T Blanco, J Merayo-Lloves, L Fabiani, S Del Olmo Aguado, S Mar-Sardana
  • ARVO Meeting Abstracts
  • 2008
1 Excerpt

The Effect of Collagen Crosslinking Using Riboflavin/UVA on the Molecular and Fibrillar Architecture of the Corneal Stroma

  • KM Meek, S Hayes, CS Kamma-Lorger, C Boote, AJ Quantock
  • Investigative Ophthalmology & Visual Science…
  • 2008
2 Excerpts

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