Ribociclib for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer

@article{Burris2018RibociclibFT,
  title={Ribociclib for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer},
  author={Howard A. Burris},
  journal={Expert Review of Anticancer Therapy},
  year={2018},
  volume={18},
  pages={201 - 213}
}
  • H. Burris
  • Published 19 February 2018
  • Medicine, Biology
  • Expert Review of Anticancer Therapy
ABSTRACT Introduction: The emergence of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors marked a significant advancement in the treatment of advanced breast cancer. Ribociclib is an orally bioavailable, highly selective inhibitor of CDK4/6. In combination with various endocrine therapies, ribociclib has demonstrated clinical activity as a first-line therapy for patients with HR+, HER2− advanced breast cancer, without compromising the favorable toxicity profile associated with endocrine… 
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