Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus.

@article{Chung2007RibavirinRA,
  title={Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus.},
  author={Dong Hoon Chung and Yanjie Sun and William B. Parker and Jeffrey B. Arterburn and Alfred A. Bartolucci and Colleen B Jonsson},
  journal={Journal of virology},
  year={2007},
  volume={81 21},
  pages={11722-9}
}
The broad spectrum of antiviral activity of ribavirin (RBV) lies in its ability to inhibit IMP dehydrogenase, which lowers cellular GTP. However, RBV can act as a potent mutagen for some RNA viruses. Previously we have shown a lack of correlation between antiviral activity and GTP repression for Hantaan virus (HTNV) and evidence for RBV's ability to promote error-prone replication. To further explore the mechanism of RBV, GTP levels, specific infectivity, and/or mutation frequency was measured… CONTINUE READING