Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications.

@article{Vignuzzi2005RibavirinAL,
  title={Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications.},
  author={Marco Vignuzzi and Jeffrey K. Stone and Raul Andino},
  journal={Virus research},
  year={2005},
  volume={107 2},
  pages={173-81}
}
Positive strand RNA virus populations are a collection of similar but genetically different viruses. They exist as viral quasispecies due to the high mutation rates of the low fidelity viral RNA-dependent RNA polymerase (RdRp). It is thought that this genomic heterogeneity is advantageous to the population, allowing for adaptation to rapidly changing… CONTINUE READING