Ribavirin analogs.

  title={Ribavirin analogs.},
  author={William W Shields and Paul J. Pockros},
  journal={Clinics in liver disease},
  volume={13 3},
Ribavirin is ineffective against hepatitis C virus as mono-therapy but is critical in attaining both early virologic response and sustained virologic response when combined with pegylated interferon. Ribavirin has significant dose-limiting toxicities, the most important of which is hemolytic anemia. Taribavirin is a ribavirin pro-drug, which targets the liver and has less incidence of anemia, and it may be a promising alternative to ribavirin in the future.