Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.

@article{Gebeyehu1985RibavirinTA,
  title={Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase.},
  author={Getinet Gebeyehu and Victor E. Marquez and A C Van Cott and David A. Cooney and James A. Kelley and Hiramagalur N Jayaram and Gurpreet S. Ahluwalia and Raymond Dion and Yvonne Wilson and David G. Johns},
  journal={Journal of medicinal chemistry},
  year={1985},
  volume={28 1},
  pages={99-105}
}
A series of dinucleotides, analogous to nicotinamide adenine dinucleotide but containing the five-membered base nucleosides tiazofurin (1a), selenazofurin (1b), ribavirin (2), and AICAR (3) in place of nicotinamide ribonucleoside, were prepared in greater than 50% yield by reacting the corresponding nucleotide imidazolidates (6a-d) with adenosine 5'-monophosphate (AMP). The symmetric dinucleotides of tiazofurin (TTD, 8e) and selenazofurin (SSD, 8f) were also prepared by a similar methodology… CONTINUE READING
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