Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP.

@article{Noshiro2004RhythmicEO,
  title={Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP.},
  author={Mitsuhide Noshiro and Takeshi Kawamoto and Masae Furukawa and Katsumi Fujimoto and Yuzo Yoshida and Eri Sasabe and Shinichi Tsutsumi and Taizo Hamada and Sato Honma and Ken-ichi Honma and Yukio Kato},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2004},
  volume={9 4},
  pages={317-29}
}
The mammalian master molecular clock consisting of several clock gene products in the suprachiasmatic nucleus (SCN) drives circadian rhythms in behaviour and physiology. Molecular clocks consisting of the same components also exist in various peripheral organs. DEC1 and DEC2, basic helix-loop-helix transcription factors, were recently reported to be involved in the central clock in the SCN. We examined the expression profile of DEC1 and DEC2 in the periphery and their roles in the regulation of… CONTINUE READING