Rhythmic degradation explains and unifies circadian transcriptome and proteome data.

@article{Lck2014RhythmicDE,
  title={Rhythmic degradation explains and unifies circadian transcriptome and proteome data.},
  author={Sarah L{\"u}ck and Kevin Thurley and Paul Florian Thaben and P{\aa}l O. Westermark},
  journal={Cell reports},
  year={2014},
  volume={9 2},
  pages={741-51}
}
The rich mammalian cellular circadian output affects thousands of genes in many cell types and has been the subject of genome-wide transcriptome and proteome studies. The results have been enigmatic because transcript peak abundances do not always follow the peaks of gene-expression activity in time. We posited that circadian degradation of mRNAs and proteins plays a pivotal role in setting their peak times. To establish guiding principles, we derived a theoretical framework that fully… CONTINUE READING