Rhythmic changes in colonic motility are regulated by period genes.

  title={Rhythmic changes in colonic motility are regulated by period genes.},
  author={Willemijntje A. Hoogerwerf and Vahakn B. Shahinian and Germaine Cornelissen and F. Halberg and Jonathon Bostwick and John C Timm and Paul A. Bartell and Vincent M. Cassone},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={298 2},
Human bowel movements usually occur during the day and seldom during the night, suggesting a role for a biological clock in the regulation of colonic motility. Research has unveiled molecular and physiological mechanisms for biological clock function in the brain; less is known about peripheral rhythmicity. This study aimed to determine whether clock genes such as period 1 (per1) and period2 (per2) modulate rhythmic changes in colonic motility. Organ bath studies, intracolonic pressure… CONTINUE READING
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