Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.

@article{Preussner2014RhythmicUA,
  title={Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.},
  author={Marco Preussner and Ilka Wilhelmi and Astrid-Solveig Schultz and Florian Finkernagel and Monika Michel and Tarik Moeroey and Florian Heyd},
  journal={Molecular cell},
  year={2014},
  volume={54 4},
  pages={651-62}
}
The circadian clock drives daily rhythms in gene expression to control metabolism, behavior, and physiology; while the underlying transcriptional feedback loops are well defined, the impact of alternative splicing on circadian biology remains poorly understood. Here we describe a robust circadian and light-inducible splicing switch that changes the reading frame of the mouse mRNA encoding U2-auxiliary-factor 26 (U2AF26). This results in translation far into the 3' UTR, generating a C terminus… CONTINUE READING
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