Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity.

@article{Kalra2003RhythmicRG,
  title={Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity.},
  author={Satya P. Kalra and Michela Bagnasco and Effiong E Otukonyong and Michael G Dube and Pushpa S. Kalra},
  journal={Regulatory peptides},
  year={2003},
  volume={111 1-3},
  pages={1-11}
}
The hypothalamus integrates metabolic, neural and hormonal signals to evoke an intermittent appetitive drive in the daily management of energy homeostasis. Three major players identified recently in the feedback communication between the periphery and hypothalamus are leptin, ghrelin and neuropeptide Y (NPY). We propose that reciprocal circadian and ultradian rhythmicities in the afferent humoral signals, anorexigenic leptin from adipocytes and orexigenic ghrelin from stomach, encode a… CONTINUE READING