Rhus verniciflua Stokes prevents cisplatin-induced cytotoxicity and reactive oxygen species production in MDCK-I renal cells and intact mice.

@article{Lee2009RhusVS,
  title={Rhus verniciflua Stokes prevents cisplatin-induced cytotoxicity and reactive oxygen species production in MDCK-I renal cells and intact mice.},
  author={Joo-Ho Lee and Hyo-Jung O. Lee and Hyo-Jeong Lee and Won-cheol Choi and Seong-woo Yoon and Seong-Gyu Ko and Kwang Seok Ahn and Seung-Hoon Choi and Kyoo-Seok Ahn and John Charles Lieske and Sung-Hoon Kim},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2009},
  volume={16 2-3},
  pages={188-97}
}
Cisplatin-induced oxidative stress can cause liver and kidney damage, thus limiting therapeutic efficacy. Thus, in the present study, since Rhus verniciflua Stokes (RVS) containing flavonoids has antioxidant effects, we investigated whether it can protect cisplatin-induced toxicity in vitro and in vivo, The in vitro effects of RVS on the cell viability and reactive oxygen species (ROS) production were investigated using cisplatin-treated Madin-Darby Canine kidney (MDCK)-I renal cells. Its in… CONTINUE READING
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