Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3.

@article{Ren2013RhomboidDC,
  title={Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3.},
  author={Xiaoxia Ren and Wei Song and Wenjie Liu and Xin Guan and Fei Miao and Shiying Miao and Linfang Wang},
  journal={FEBS letters},
  year={2013},
  volume={587 12},
  pages={1793-8}
}
We have previously reported that rhomboid domain containing 1 (RHBDD1), a new member of the Rhomboid family, is highly expressed in testis. In the present work, luciferase analyses showed that RHBDD1 enhanced the AP-1 activity in a dose- and activity-dependent manner. RHBDD1 overexpression increased c-Jun activity, and the activity was visibly inhibited when RHBDD1 was knocked down. The suppression of c-Jun by inactivation of RHBDD1 was rescued by overexpressing RHBDD1. However, c-Jun… CONTINUE READING