Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz.

@article{Bang2000RhomboidAS,
  title={Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz.},
  author={Anne G Bang and Chris Kintner},
  journal={Genes & development},
  year={2000},
  volume={14 2},
  pages={
          177-86
        }
}
Activation of the Drosophila epidermal growth factor receptor (DER) by the transmembrane ligand, Spitz (Spi), requires two additional transmembrane proteins, Rhomboid and Star. Genetic evidence suggests that Rhomboid and Star facilitate DER signaling by processing membrane-bound Spi (mSpi) to an active, soluble form. To test this model, we use an assay based on Xenopus animal cap explants in which Spi activation of DER is Rhomboid and Star dependent. We show that Spi is on the cell surface but… CONTINUE READING

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