Rhodostomin inhibits thrombin-enhanced adhesion of ROS 17/2.8 cells through the blockade of alphavbeta3 integrin.

@article{Yang2005RhodostominIT,
  title={Rhodostomin inhibits thrombin-enhanced adhesion of ROS 17/2.8 cells through the blockade of alphavbeta3 integrin.},
  author={R S Yang and Huei-Shien Chiang and Chih-Hsin Tang and Chia-Shin Yeh and T. F. Huang},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={46 4},
  pages={387-93}
}
Osteosarcoma is a very malignant bone tumor which has a high metastatic potential and usually lead to poor prognosis. The adhesion of tumor cells to the endothelium or extracellular matrix (ECM) is an essential step in the metastatic cascade. We investigated the effect of thrombin on the adhesion activity of the osteosarcoma cell line, ROS 17/2.8. Incubation with the low concentrations of thrombin (0.01-5 U/ml, 5 min to 24 h) elevated the adhesion activity of ROS 17/2.8 to both human umbilical… CONTINUE READING