Rhodopsin mutants discriminate sites important for the activation of rhodopsin kinase and Gt.

@article{Shi1995RhodopsinMD,
  title={Rhodopsin mutants discriminate sites important for the activation of rhodopsin kinase and Gt.},
  author={Wuxian Shi and Shoji Osawa and Cheryl D. Dickerson and Ellen R. Weiss},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 5},
  pages={2112-9}
}
The cytoplasmic loops of rhodopsin, the rod cell photoreceptor, play important regulatory roles in the activation of both rhodopsin kinase and the rod cell G protein, Gt. A number of studies have identified domains in rhodopsin that are important for the activation of Gt. However, less is known concerning the cytoplasmic regions that regulate phosphorylation of the photoreceptor by rhodopsin kinase. To identify regions that participate in these processes, a series of alanine mutations were… CONTINUE READING

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