Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods

@inproceedings{Frederiksen2016RhodopsinKA,
  title={Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods},
  author={Rikard Frederiksen and Soile Nymark and Alexander V Kolesnikov and Justin Berry and Leopold Adler and Yiannis Koutalos and Vladimir J Kefalov and M Carter Cornwall},
  booktitle={The Journal of general physiology},
  year={2016}
}
Photoactivation of vertebrate rhodopsin converts it to the physiologically active Meta II (R*) state, which triggers the rod light response. Meta II is rapidly inactivated by the phosphorylation of C-terminal serine and threonine residues by G-protein receptor kinase (Grk1) and subsequent binding of arrestin 1 (Arr1). Meta II exists in equilibrium with the more stable inactive form of rhodopsin, Meta III. Dark adaptation of rods requires the complete thermal decay of Meta II/Meta III into opsin… CONTINUE READING
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