Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum

@article{Kim2011RhododendrinAA,
  title={Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum},
  author={Myung-Hoe Kim and Agung Endro Nugroho and Jongwon Choi and Jong Hee Park and Hee-Juhn Park},
  journal={Archives of Pharmacal Research},
  year={2011},
  volume={34},
  pages={971-978}
}
To identify an analgesic/anti-inflammatory component from the leaves of Rhododendron aureum (Ericaceae), phytochemical isolation and pharmacological assays (writhing assays and vascular permeability assay for analgesic action in mice; carrageenan-induced paw edemaand TPA-induced ear edema assays of anti-inflammatory action in rats) were performed. Four compounds were isolated from the active fraction (BuOH fraction) by silica gel column chromatography and identified as (−)-rhododendrol… 
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References

SHOWING 1-10 OF 20 REFERENCES
Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects.
Antinociceptive anti-inflammatory effect of Monotropein isolated from the root of Morinda officinalis.
TLDR
Results indicate that monotropein contributes to the antinociceptive and anti-inflammatory action of Morinda officinalis root.
Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin.
TLDR
The results suggest that the anti-inflammatory and antinociceptive effects of syringin after oral administration may be attributed to its in vivo transformation to sinapyl alcohol.
Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica.
TLDR
Euscaphic acid exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
Flavonoids from the flower ofRhododendron yedoense var.Poukhanense and their antioxidant activities
Antioxidant flavonoids have been isolated from the flower ofRhododendron yedoense var.poukhanense. One new flavonoid and three known flavonoids, quercetin-5-O-β-D-glucopyranoside (1), quercetin (3),…
Rhododendrol glycosides and phenyl glucoside esters from inner bark of Betula pubescens
Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica.
19Alpha-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa.
TLDR
The results suggest that 19alpha-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.
(+)-rhododendrol and epi-rhododendrin suppress the NO production by activated macrophages in vivo.
TLDR
The results suggest that (+)-rhododendrol (1) and epi-r Rhododendrin (2) contribute in part to the anti-inflammatory effect of A. nikoense.
In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells.
TLDR
The results suggest that the 23-hydroxyursolic acid-mediated inhibition of iNOS and COX-2 expression, via blocking NF- kappaB activation, may mechanistically responsible for the anti-inflammatory effects of Cussonia bancoensis stem bark in vitro.
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