Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.

@article{Choi2012RhododendricAA,
  title={Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.},
  author={Yeon ho Choi and Wei Zhou and Joonseok Oh and Sanggil Choe and Dong Woo Kim and Seung Ho Lee and MinKyun Na},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2012},
  volume={22 19},
  pages={
          6116-9
        }
}
  • Y. ChoiWei Zhou M. Na
  • Published 1 October 2012
  • Chemistry
  • Bioorganic & medicinal chemistry letters
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40 Citations
Background Citations
7
Methods Citations
1

40 Citations

Rhododendric Acid A, a New Ursane‐Type PTP1B Inhibitor from the Endangered Plant Rhododendron brachycarpum G. Don.

The bioassay-guided fractionation on the leaves of R.brachycarpum G.Don (Ericaceae) delivers seven PTP1B inhibitory triterpenoids, including the new triterpene, rhododendric acid A (I).

The first cyclomegastigmane rhododendroside A from Rhododendron brachycarpum alleviates HMGB1-induced sepsis.

Isolation and Structure Determination of PTP1B Inhibitor from Streptomyces sp. Strain TD-X10

The results highlight the antidiabetic potential of natural products from actinobacteria, particularly Streptomyces species.

Chemical constituents of the Korean endangered species Rhododendron brachycarpum

Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Salvia amarissima Ortega

An infusion prepared from the aerial parts of Salvia amarissima Ortega inhibited the enzyme protein tyrosine phosphatase 1B (PTP-1B) and a new neo-clerodane type diterpenoid glucoside, named amarisolide G (8a,b), is reported for the first time for the species.

Phytochemical Studies of Korean Endangered Plants: A New Flavone from Rhododendron brachycarpum G.Don

Globally at least 13% of known flora are endangered or threatened and the rate of the global biodiversity decline is not improving. 1 The USDA claims that there are now over 780 endangered or…

Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents

This review discusses the development of potent natural and semisynthetic PTP1B inhibitors with IC50 values under 10 μM over the past six years, including their structural features, biological features, structure–activity relationships (SARs), and strategies for identifying potent PTP 1B inhibitors from natural products to provide useful information for use by medicinal chemists in developing potent PTB inhibitors as T2DM treatments.

Triterpenoids from the twigs and leaves of Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

The potential use of these triterpenes against human pathogens, including their mechanisms of action, via in vivo studies, and the future perspectives about the use of compounds for human or even animal health are discussed.

The genus Rhododendron: an ethnopharmacological and toxicological review.

26 References

Protein tyrosine phosphatase 1B inhibitory by dammaranes from Vietnamese Giao-Co-Lam tea.

Protein tyrosine phosphatase 1B inhibitory activity of 24‐norursane triterpenes isolated from Weigela subsessilis

The findings indicate that the free carboxyl group at C‐28 in this type of triterpenes plays a critical role in the inhibition of PTP1B.

Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata.

The results indicate that the substitution of hydroxy groups on the ursane-type triterpenes is responsible for the loss of activity, and thus 1 and 2 possessing only one or two hydroxy Groups can be potential PTP1B inhibitors.

Protein tyrosine phosphatase 1B inhibitors from Morus root bark.

    L. CuiM. Na J. Ahn
    Chemistry
    Bioorganic & medicinal chemistry letters
  • 2006

Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana.

    M. NaL. Cui J. Ahn
    Chemistry, Biology
    Bioorganic & medicinal chemistry letters
  • 2006

PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.

Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii.

Bioassay-guided fractionation of an EtOAc-soluble extract of the root bark of Erythrina mildbraedii, using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new isoprenylated flavonoids, abyssinone-IV-4'-O-methyl ether, which may be considered as a new class of P TP1B inhibitors.

Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity.

Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting

Four lines of evidence from historical drug data, 13,548 marine natural products, 767 medicinal plants, and 19,721 bioactive natural products suggest that drugs are derived mostly from preexisting drug-productive families.

Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet.

It is suggested that BA has an antiobese potential through modulation of fat and carbohydrate metabolism, and it may be a suitable lead compound in the treatment of obesity.