Rhodium(III)-Catalyzed Oxadiazole-Directed Alkenyl C-H Activation for Synthetic Access to 2-Acylamino and 2-Amino Pyridines.

Abstract

We report herein a Rh(III)-catalyzed alkenyl C-H activation protocol for the coupling of oxadiazoles with alkynes and synthesis of 2-acylamino and 2-amino pyridines, an important heterocyclic scaffold for various naturals products and synthetic pharmaceuticals bearing a readily reacting functional group. The selective protection/deprotection of amino groups through simple solvent switching, good functional group compatibility, superior product yield, and high regioselectivity are some of the notable synthetic features witnessed in this reaction protocol.

DOI: 10.1021/acs.joc.7b01303

Cite this paper

@article{Yang2017RhodiumIIICatalyzedOA, title={Rhodium(III)-Catalyzed Oxadiazole-Directed Alkenyl C-H Activation for Synthetic Access to 2-Acylamino and 2-Amino Pyridines.}, author={Fan Yang and Jiaojiao Yu and Yun Liu and Jin Zhu}, journal={The Journal of organic chemistry}, year={2017}, volume={82 19}, pages={9978-9987} }