Rhodiola crenulata induces an early estrogenic response and reduces proliferation and tumorsphere formation over time in MCF7 breast cancer cells.

@article{Bassa2016RhodiolaCI,
  title={Rhodiola crenulata induces an early estrogenic response and reduces proliferation and tumorsphere formation over time in MCF7 breast cancer cells.},
  author={Lotfi M. Bassa and Cody Jacobs and Kelly J. Gregory and Elizabeth M. Henchey and Jennifer Ser-Dolansky and Sallie S Schneider},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2016},
  volume={23 1},
  pages={
          87-94
        }
}
BACKGROUND Rhodiola crenulata is a Tibetan mountainous plant, commonly used in Eastern alternative medicine. Many phytochemicals possess estrogenic activity, a critical regulator of proliferation in mammary epithelial cells. We have previously characterized anti-cancer properties of R. crenulata in aggressive triple negative breast cancer cells, lacking the expression of estrogen receptor. Currently, it is unknown whether R. crenulata exerts estrogenic effects and as such consumption may be a… CONTINUE READING
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