Rhodamine B conjugates of triterpenoic acids are cytotoxic mitocans even at nanomolar concentrations.


Triterpenoic acids 1-6 exhibited very low or no cytotoxicity at all, but their corresponding 2,3-di-O-acetyl-piperazinyl amides 13-18 showed low EC50 values for several human tumor cell lines. Their cytotoxicity, however, was also high for the non-malignant mouse fibroblasts NIH 3T3. A significant improvement was achieved by preparing the rhodamine B… (More)
DOI: 10.1016/j.ejmech.2016.12.040


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