Rhodamine 123 efflux transporter in Haloferax volcanii is induced when cultured under 'metabolic stress' by amino acids: the efflux system resembles that in a doxorubicin-resistant mutant.

@article{Kaidoh1996Rhodamine1E,
  title={Rhodamine 123 efflux transporter in Haloferax volcanii is induced when cultured under 'metabolic stress' by amino acids: the efflux system resembles that in a doxorubicin-resistant mutant.},
  author={Kouich Kaidoh and Seiji Miyauchi and Akihito Abe and Shigeru Tanabu and Toshifumi Nara and Naoki Kamo},
  journal={The Biochemical journal},
  year={1996},
  volume={314 ( Pt 1)},
  pages={355-9}
}
In this paper, we report that an archaebacterium, Haloferax volcanii, cultured in medium containing a large excess of amino acids showed very low levels of rhodamine 123 (RH123), which is a potent substrate for P-glycoprotein and the bacterial multidrug efflux transporter. This low level involved the active efflux of RH123 from the cells. The level of intracellular RH123 was increased and the efflux inhibited by the Ca2+-channel antagonist verapamil and also by various anti-cancer drugs. The… CONTINUE READING

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