Rhodamine-123: a p-glycoprotein marker complex with sodium lauryl sulfate.

Abstract

Aim of this study was to investigate the role of sodium lauryl sulfate (SLS) as P-glycoprotein inhibitor. The everted rat gut sac model was used to study in-vitro mucosal to serosal transport of Rhodamine-123 (Rho-123). Surprisingly, SLS decreases the serosal absorption of Rho-123 at all investigated concentrations. Investigation reveals complex formation… (More)

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@article{AlMohizea2015Rhodamine123AP, title={Rhodamine-123: a p-glycoprotein marker complex with sodium lauryl sulfate.}, author={Abdullah Mohammed Al-Mohizea and Fahad I Al-jenoobi and Mohd Aftab Alam}, journal={Pakistan journal of pharmaceutical sciences}, year={2015}, volume={28 2}, pages={617-22} }